Abstract:

Stroma cell-derived factor (SDF-1), also known as CXC chemokine receptor 4 (CXCL12) chemokine, was first isolated from bone marrow stromal cells. CXCR4 receptor is a kind of polyhedral molecules which can be closely integrated with the SDF-1. SDF-1 and the receptor CXCR4 biological axis has an important role in mediating hematopoietic stem cell migration and homing, inflammatory reaction and the metastasis of malignant tumor. Researches confirmed that the SDF-1 / CXCR4 also expressed in normal eye tissue, and increaseed abnormally in the formation of ocular angiogenesis and the glial scar. In terms of angiogenesis of eye, SDF-1/CXCR4 provides an important target in the treatment of ocular angiogenesis disease. This article reviews the role of the SDF-1 and the receptor CXCR4  is closely related to a variety of  eye diseases, including pterygium, corneal transplant and corneal alkali burn, retinal proliferative diseases, optic nerve injury, ocular cancer and so on.